Pure akinesia due to lewy body Parkinson's disease: A case with pathology
Identifieur interne : 006435 ( Main/Exploration ); précédent : 006434; suivant : 006436Pure akinesia due to lewy body Parkinson's disease: A case with pathology
Auteurs : N. P. Quinn ; P. Luthert ; M. Honavar ; C. D. Marsden [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1989.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Congélation, Homme.
English descriptors
- KwdEn :
- Akinesia, Antiparkinson Agents (therapeutic use), Autopsy, Brain, Brain (pathology), Case study, Clinical form, DL‐threo‐DOPS, Degenerative disease, Exploration, Freezing, Human, Humans, Inclusion Bodies (ultrastructure), Levodopa, Lewy body Parkinson's, Locus Coeruleus (pathology), Male, Middle Aged, Motor system disorder, Nervous system diseases, Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson disease, Pathology, Substantia Nigra (pathology).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- drug therapy : Parkinson Disease.
- pathology : Brain, Locus Coeruleus, Parkinson Disease, Substantia Nigra.
- ultrastructure : Inclusion Bodies.
- Humans, Male, Middle Aged.
Abstract
The case of a patient with levodopa‐responsive pure akinesia and freezing of gait for 17 years, whose brain showed the classical changes of Lewy body Parkinson's disease at postmortem is presented. A short trial of DL‐threo–DOPS was ineffective. Intellectual function was preserved despite the presence of Lewy bodies and mild cell loss in subcortical cholinergic nuclei. Pure akinesia is likely to be a heterogeneous condition, with most cases having little or no response to levodopa therapy. However, this case demonstrates that this clinical picture may be caused by Lewy body Parkinson's disease.
Url:
DOI: 10.1002/mds.870040112
Affiliations:
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Le document en format XML
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P." last="Quinn">N. P. Quinn</name><affiliation><wicri:noCountry code="subField">London SE5</wicri:noCountry></affiliation></author><author><name sortKey="Luthert, P" sort="Luthert, P" uniqKey="Luthert P" first="P." last="Luthert">P. Luthert</name><affiliation><wicri:noCountry code="subField">London SE5</wicri:noCountry></affiliation></author><author><name sortKey="Honavar, M" sort="Honavar, M" uniqKey="Honavar M" first="M." last="Honavar">M. Honavar</name><affiliation><wicri:noCountry code="subField">London SE5</wicri:noCountry></affiliation></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Institute of Neurology, Queen Square, London</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1989">1989</date><biblScope unit="vol">4</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="85">85</biblScope><biblScope unit="page" to="89">89</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A27FD5B73958E6F38F9F3870172ED0AD7E8BE0B8</idno><idno type="DOI">10.1002/mds.870040112</idno><idno type="ArticleID">MDS870040112</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Akinesia</term><term>Antiparkinson Agents (therapeutic use)</term><term>Autopsy</term><term>Brain</term><term>Brain (pathology)</term><term>Case study</term><term>Clinical form</term><term>DL‐threo‐DOPS</term><term>Degenerative disease</term><term>Exploration</term><term>Freezing</term><term>Human</term><term>Humans</term><term>Inclusion Bodies (ultrastructure)</term><term>Levodopa</term><term>Lewy body Parkinson's</term><term>Locus Coeruleus (pathology)</term><term>Male</term><term>Middle Aged</term><term>Motor system disorder</term><term>Nervous system diseases</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (pathology)</term><term>Parkinson disease</term><term>Pathology</term><term>Substantia Nigra (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Akinésie</term><term>Anatomopathologie</term><term>Autopsie</term><term>Corps Lewy</term><term>Encéphale</term><term>Etude cas</term><term>Exploration</term><term>Forme clinique</term><term>Homme</term><term>Maladie dégénérative</term><term>Parkinson maladie</term><term>Système nerveux pathologie</term><term>Trouble moteur</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Congélation</term><term>Homme</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Locus Coeruleus</term><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Inclusion Bodies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The case of a patient with levodopa‐responsive pure akinesia and freezing of gait for 17 years, whose brain showed the classical changes of Lewy body Parkinson's disease at postmortem is presented. A short trial of DL‐threo–DOPS was ineffective. Intellectual function was preserved despite the presence of Lewy bodies and mild cell loss in subcortical cholinergic nuclei. Pure akinesia is likely to be a heterogeneous condition, with most cases having little or no response to levodopa therapy. However, this case demonstrates that this clinical picture may be caused by Lewy body Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><noCountry><name sortKey="Honavar, M" sort="Honavar, M" uniqKey="Honavar M" first="M." last="Honavar">M. Honavar</name><name sortKey="Luthert, P" sort="Luthert, P" uniqKey="Luthert P" first="P." last="Luthert">P. Luthert</name><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N. P." last="Quinn">N. P. Quinn</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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